UPC2 — Aspergillus fumigatus

Summary

AFU1G01960 (UPC2) in Aspergillus fumigatus encodes a Zn(II)2Cys6 transcription factor with DNA-binding transcription activator activity specific to RNA polymerase II. It is associated with ergosterol metabolism and sterol homeostasis, as well as the positive regulation of transcription by RNA polymerase II and cellular response to xenobiotic stimuli. The gene is linked to sterol uptake regulation and has been connected to reduced virulence in studies of related genes in other species, where the family is implicated in disseminated candidiasis. Localised to the nucleus, UPC2 also shows associations with downregulation of DNA-dependent transcription and general homeostasis processes.