COX2 — Aspergillus fumigatus

Summary

AFUMT00120 (COX2, AfCOX2) encodes cytochrome c oxidase subunit 2, a copper-binding cupredoxin domain protein that forms part of respiratory chain complex IV. This mitochondrial inner membrane protein has cytochrome-c oxidase activity (EC 7.1.1.9) and is associated with ATP synthesis coupled electron transport and mitochondrial electron transport from cytochrome c to oxygen. The gene is linked to numerous phenotypes including decreased lifespan, absent respiratory metabolism, absent desiccation resistance, decreased mitochondrial transport, increased mutation frequency, delayed cell cycle progression, and absent mitophagy. It is also associated with increased nitrogen source utilization, decreased necrotic cell death, and increased polyploidy. Studies of related genes in other species connect the COX2 family to assembly factors COX18, COA6, and SHY1.