PRX1 — Aspergillus fumigatus

Summary

AFU8G07130 (symbol PRX1, preferred name AfPRX1) on Aspergillus fumigatus chromosome 8 encodes a putative AhpC/TSA family thioredoxin peroxidase, a member of the 1-Cys peroxiredoxin family with thioredoxin-dependent peroxiredoxin activity. The gene is associated with cellular responses to oxidative stress, including hydrogen peroxide detoxification and cell redox homeostasis, as well as with filamentous growth in response to chemical stimuli and starvation, fungal-type cell wall organization, and interaction with the host. It has been linked to the hyphal cell wall, cytoplasm, and nucleus. Associations include increased biofilm formation, altered redox state, increased lifespan, decreased anaerobic and respiratory metabolism, increased mutation frequency, increased vegetative growth, and increased telomere length. Related genes in other species are linked to mitochondrial peroxiredoxin function.