crz1 — Aspergillus fumigatus

Summary

AFU8G04290 (symbol crz1) in Aspergillus fumigatus chromosome 8 encodes a C2H2 zinc finger domain protein, a putative C2H2 finger domain protein that binds DNA and zinc. It is annotated to the nucleus and associated with regulation of transcription by RNA polymerase II, signal transduction, TOR signaling, and homeostasis. The gene is linked to hyphal growth, thigmotropism, developmental induction, and response to nutrient. Studies of related genes in other species connect the crz1 family to loss of pathogenicity and to diseases such as septoria nodorum blotch in wheat, as well as to interactions with Verticillium dahliae and Fusarium oxysporum pathovars.