ERG10 — Aspergillus fumigatus

Summary

AFU8G04000 (ERG10, erg10B) in Aspergillus fumigatus encodes a thiolase family protein with acetyl-CoA C-acetyltransferase activity (EC 2.3.1.9). The gene is associated with the isoprenoid pathway, ergosterol anabolism, sterol homeostasis, and fatty acid beta-oxidation. Its product localises to the peroxisome, mitochondria, and cytosol. ERG10 is linked to invasive pulmonary aspergillosis and a lethal pathogen phenotype. Additional associations include abnormal cell cycle progression, meiosis, sporulation, increased cell size, decreased freeze-thaw resistance, increased replicative lifespan, and altered protein modification. Related genes in other species are linked to abnormal cytokinesis, mitochondrial morphology, and inviability.