mfsB — Aspergillus fumigatus

Summary

AFU8G04150 (mfsB) on chromosome 8 of Aspergillus fumigatus encodes a transmembrane transporter belonging to the major facilitator superfamily (MFS), with a TetR/TetA-MdtG domain. The gene is associated with pigmentation, hyphal growth, and homeostasis, and its product localises to the plasma membrane and membrane. It has been connected to a wide network of related genes, including bbp-1, ptcB, and fap1, though no direct molecular function beyond transporter activity is established in this species. Studies of related genes in other species link the MFS family to cytoplasmic and apoplastic effector functions, as well as traits such as phosphorus concentration, germination rate, and oxidative stress response, but these associations are not confirmed for mfsB itself.