cat1 — Aspergillus fumigatus

Summary

AFU8G00800 (symbol cat1) on chromosome 8 of Aspergillus fumigatus encodes a putative amino acid transporter belonging to the APC/YAT family, with L-arginine and L-lysine transporter activity and general amino acid permease activity. The gene is associated with detoxification of hydrogen peroxide, regulation of morphogenesis, nucleotide and melanin anabolism, autolysis, asexual reproduction and sporulation, filamentous growth, secondary metabolism, and regulation of nitrogen utilization. It is linked to L-arginine and L-lysine import, amino acid membrane transport, and developmental processes. The encoded product localizes to the plasma membrane, cell tip, fungal-type cell wall, vacuole, Golgi membrane, and cell division site. Studies of related genes in other species connect the family to plasma membrane amino acid transport.