hsfA — Aspergillus fumigatus

Summary

AFU7G08320 (symbol hsfA) on chromosome 7 of Aspergillus fumigatus encodes a heat shock transcription factor, putative, with a conserved HSF DNA-binding domain and is annotated with DNA-binding transcription activator activity, RNA polymerase II-specific. The gene is associated with the cellular response to heat, positive regulation of transcription by RNA polymerase II, and DNA-dependent transcription. It has also been linked to unsaturated fatty acid metabolism, fatty acid metabolism, secondary metabolism, lipid homeostasis, and broader homeostatic processes. The encoded protein localises to the nucleus, cytoplasm, cytosol, and chromatin. Related genes in other species, including the A. fumigatus gene AFU5G01900 and the fission yeast SPAC2E12.02.1, further connect this family to stress-responsive transcriptional regulation.