ftmPT1 — Aspergillus fumigatus

Summary

AFU8G00210 (symbol ftmPT1) on Aspergillus fumigatus chromosome 8 encodes a prenyltransferase with tryptophan dimethylallyltransferase activity (EC 2.5.1.106) and aminopeptidase activity (EC 3.4.11.17), belonging to the DMATS-type aromatic prenyltransferase family. The gene is associated with alkaloid anabolism, specifically verruculogen anabolism, fumigaclavine C anabolism, and ergot alkaloid anabolism, as well as prenylation and proteolysis. Studies of related genes in other species, including dmaW and cpd1, link the family to tryptophan prenylation and alkaloid pathway steps, though these associations are not established for this gene.