CLM2 — Aspergillus fumigatus

Summary

AFU8G00510 (CLM2, also known as fmaG) on chromosome 8 of Aspergillus fumigatus encodes a fungal cytochrome P450 monooxygenase with aflatoxin B synthase activity, heme and iron binding, and oxidoreductase activity acting on paired donors. This gene is associated with fumagillin anabolism, sterol homeostasis, demethylation, fatty acid oxidation, asexual reproduction and sporulation, and is linked to membrane localisation. Phenotypic associations include decreased micronucleophagy and ribophagy, increased cell death, arrested vegetative and exponential growth, abnormal cell cycle progression, decreased invasive growth, and altered nutrient utilization. Studies of related genes in other species connect the family to increased virulence.