CLM2 — Aspergillus fumigatus

Summary

AFU8G00560 (CLM2, also known as psoD) on chromosome 8 of Aspergillus fumigatus encodes a cytochrome P450 monooxygenase, a member of the fungal cytochrome P450 family with heme binding, iron binding and oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen. This gene is associated with sterol homeostasis, demethylation, asexual reproduction and sporulation, as well as fatty acid oxidation, prenylation, protein farnesylation, mitochondrial fission, and inflammatory response. It is linked to membrane localisation and to numerous phenotypes including decreased resistance to ionizing radiation and hyperosmotic stress, increased cell death, arrested vegetative and exponential growth, abnormal cell cycle progression, decreased invasive growth, and altered nutrient utilization. Studies of related genes in other species connect the family to ergosterol biosynthesis.