ftmA — Aspergillus fumigatus

Summary

AFU8G00170 (ftmA) on chromosome 8 of Aspergillus fumigatus encodes a non-ribosomal peptide synthetase (NRPS) with ligase, transferase, and isomerase activities, and contains domains including an adenylation domain, condensation domain, and phosphopantetheine attachment site. The gene is associated with the biosynthesis of several secondary metabolites, including brevianamide F, fumitremorgin B, and verruculogen, as well as general non-ribosomal peptide and alkaloid metabolism. It is linked to amino acid activation for non-ribosomal peptide biosynthesis and is localized to the cytoplasm. Studies of related genes in other species, such as dtpA and notE, connect the family to additional peptide and amino acid ligase activities, though these associations are not yet established for ftmA itself.