AGC1 — Aspergillus fumigatus

Summary

AFU7G05220, designated AGC1 (AfAGC1) in Aspergillus fumigatus on chromosome 7, encodes a mitochondrial carrier protein of the Mito_Solute_Carrier family, possessing EF-hand calcium-binding domains and multiple transmembrane transporter activities. The gene product is annotated as a transmembrane transporter for L-ornithine, ferrous iron, pyrimidine nucleotides, aspartate:glutamate, 2-oxoglutarate, glycine, magnesium, dicarboxylic acids, succinate:fumarate, thiamine diphosphate, L-aspartate, and L-glutamate. It localises to the mitochondrial inner membrane and is associated with mitochondrial transport processes including iron, pyrimidine nucleotide, L-ornithine, 2-oxoglutarate, glycine, aspartate, and glutamate import, as well as the malate-aspartate shuttle, heme and arginine anabolism, and homeostasis. Phenotypic associations link AGC1 to altered cell cycle progression, budding patterns, cell size, vegetative growth, chitin deposition, desiccation resistance, carbon source utilisation, peroxisomal transport and morphology, and thermotolerance. Related genes in other species are linked to respiratory growth.