atrR — Aspergillus fumigatus

Summary

AFU7G06320 (atrR) on chromosome 7 of Aspergillus fumigatus encodes a C6 transcription factor with a Zn2Cys6 DNA-binding domain, classified as an AtrR-like protein. It is annotated for sequence-specific DNA binding and RNA polymerase II cis-regulatory region binding, consistent with its role as a DNA-binding transcription factor. The gene is associated with siderophore anabolism, reductive iron assimilation, ergosterol and sterol anabolism, sterol homeostasis, biofilm formation, hyphal growth, and hypersensitivity. It is linked to positive regulation of transcription by RNA polymerase II and positive regulation of metabolism. Localisation evidence connects the product to both the nucleus and membrane. Related genes in other species link the family to reduced virulence and pulmonary aspergillosis.