gprM — Aspergillus fumigatus

Summary

AFU7G05300 (symbol gprM) on Aspergillus fumigatus chromosome 7 encodes a G-protein coupled receptor of the GPR1/git3-like family, localised to the plasma membrane. The gene is associated with signal transduction, melanin anabolism, and mycotoxin anabolism, as annotated by ontology terms. It has also been linked to invasive aspergillosis and to the Galleria mellonella infection model. Studies of related genes in other species connect the family to G-protein coupled receptor 2 secretin-like domains and to pathogens including Verticillium dahliae and Fusarium oxysporum strains, though these associations are not established for this gene.