ARN1 — Aspergillus fumigatus

Summary

AFU7G06060 (symbol ARN1, also known as SIT1) in Aspergillus fumigatus chromosome 7 encodes a major facilitator superfamily (MFS) transporter with enterochelin and iron-siderophore transporter activity. The gene is associated with siderophore metabolism, ferric triacetylfusarinine C import, siderophore-iron import, reductive iron assimilation, cellular response to iron starvation, iron homeostasis, and iron transport. It has been linked to endosome, vacuolar membrane, and plasma membrane localisation, as well as membrane transport, secretion, NO storage, and regulation of gene expression. Phenotypic associations include decreased utilization of iron sources, increased ionic stress resistance, altered cell cycle progression in G1 phase, decreased invasive and pseudohyphal growth, increased mitophagy and respiratory growth, and abnormal liquid culture appearance. Related genes in other species link the family to siderophore-iron transport, though pathogenicity appears unaffected in related species.