MTR10 — Aspergillus fumigatus

Summary

AFU7G05970 (AfMTR10) encodes a putative mRNA transport regulator (Mtr10) that belongs to the importin-beta-like family and possesses nuclear import signal receptor activity and small GTPase binding. The gene is associated with RNA and protein nuclear import, tRNA processing, RNA anabolism, sporulation, and hyphal growth. The encoded product localizes to the nuclear envelope, cytoplasm, cytosol, and nucleus. Phenotypic associations include absent or abnormal nuclear import and export, decreased lifespan, delayed meiotic recombination, arrested cell cycle progression in telophase and late anaphase, decreased radiation resistance, abnormal septum formation, and altered nutrient utilization. The gene is also linked to increased UV resistance, decreased fermentative growth, and abnormal peroxisomal morphology.