ADN2 — Aspergillus fumigatus

Summary

AFU7G02260 (symbol ADN2, also known as somA and ADN3) in Aspergillus fumigatus encodes a transcription coactivator with RNA polymerase II-specific DNA-binding activity, containing a LisH domain. The gene is associated with diverse biological processes including cell wall polysaccharide and sterol anabolism, glycan and nucleotide-sugar metabolism, secondary metabolism, biofilm formation, flocculation, cell adhesion, pseudohyphal and filamentous growth, spore formation, and positive regulation of transcription. Its product localises to both the cytoplasm and nucleus. Studies of related genes in other species link the family to altered virulence, including hypervirulence and loss of pathogenicity, as well as to infection processes. The gene is also connected to invasive pulmonary aspergillosis.