ERG9 — Aspergillus fumigatus

Summary

AFU7G01220 (ERG9) encodes a squalene synthase, an enzyme with squalene synthase activity (EC 2.5.1.21). The gene is associated with ergosterol anabolism, isoprenoid anabolism via the mevalonate pathway, and farnesyl diphosphate metabolism. The encoded protein localises to the endoplasmic reticulum, nuclear membrane-ER network, and plasma membrane. ERG9 is associated with cell growth, cell cycle progression through the G2/M phase, entry into G0, cytokinesis, chitin deposition, septum formation, endocytosis, vacuolar transport, pexophagy, nucleophagy, micronucleophagy, hyperosmotic stress resistance, iron utilisation, protein secretion, and cell death. Studies of related genes in other species connect the family to HMG1 and other ergosterol pathway genes.