CI-1 — Aspergillus fumigatus

Summary

AFU7G01450, designated CI-1 (also known as AfERG5, AfERG5A, AfERG5B, or ERG5A/ERG5B) in Aspergillus fumigatus on chromosome 7, encodes a putative cytochrome P450 monooxygenase. The gene is annotated with aromatase, monooxygenase, and oxidoreductase activities, along with heme, FMN, and FAD binding, and is localized to the endoplasmic reticulum, membrane, and cytosol. CI-1 is associated with the biosynthesis of ergosterol, sterols, melanin, terpenoids, fumonisins, and other mycotoxins, as well as with hypersensitivity. Phenotypic associations include altered cell cycle progression (G2/M phase delay, M phase arrest), decreased meiosis, cytokinesis, and vegetative growth, increased cell death and budding, abnormal autophagy, endocytosis, vacuolar transport, cytoskeleton, mitochondrial distribution, and plasma membrane morphology, and absent micronucleophagy and protein secretion. Studies of related genes in other species link the family to potassium concentration and acid sensitivity.