UBC7 — Aspergillus fumigatus

Summary

AFU6G14130 (AfUBC7, also known as UBC7) on chromosome 6 of Aspergillus fumigatus encodes an E2 ubiquitin-conjugating enzyme with ubiquitin conjugating enzyme activity (EC 2.3.2.23), also annotated with ssDNA-dependent ATPase activity, proteasome binding, and ubiquitin-protein transferase activity. The gene is associated with diverse biological processes including cellular response to UV, protein monoubiquitination, the INMAD pathway, negative regulation of SREBP signaling, stress-induced protein degradation, the N-end rule pathway, mitotic G1 DNA damage checkpoint, and error-free translesion synthesis. It localizes to multiple complexes such as the UBR1-RAD6, Rad6-Rad18, and HULC complexes, as well as heterochromatin, telomeric regions, the fungal biofilm matrix, and the ER. Phenotypic associations include increased UV resistance, decreased meiosis and meiotic recombination, increased mating response, altered cell cycle progression, and abnormal protein secretion. Studies of related genes in other species link the family to increased virulence.