erg10 — Aspergillus fumigatus

Summary

AFU6G14200 (symbol erg10) on chromosome 6 of Aspergillus fumigatus encodes an acetyl-CoA C-acetyltransferase (EC 2.3.1.9), a thiolase-family enzyme that also binds metal ions. The gene is associated with isoprenoid pathway, ergosterol anabolism, sterol homeostasis, fatty acid beta-oxidation, and general homeostasis. Its product localises to the peroxisome, mitochondria, and cytosol. Studies of related genes in other species link the family to lethal phenotypes and invasive pulmonary aspergillosis, as well as to pathogens such as Verticillium dahliae and Fusarium oxysporum pathovars.