RBD2 — Aspergillus fumigatus

Summary

AFU6G12750 (symbol RBD2, also known as AfRBD2) on chromosome 6 of Aspergillus fumigatus encodes a protein with a Peptidase_S54_rhomboid domain and rhomboid-like superfamily domain, with serine-type endopeptidase activity (EC 3.4.21.105) and protein binding, bridging function. The gene is associated with proteolysis and SREBP signalling, and its product localises to the nuclear periphery, Golgi membrane, Golgi complex, and membrane. RBD2 is linked to pulmonary aspergillosis, with experimental associations in Galleria mellonella and Mus musculus models. Related genes in other species, including Verticillium dahliae and Fusarium oxysporum pathovars, are associated with rhomboid proteases, though these findings are not established for this gene.