PMP20 — Aspergillus fumigatus

Summary

AFU6G12500 (symbol PMP20, preferred name AfPMP20) on chromosome 6 of Aspergillus fumigatus encodes an AhpC/TSA family protein with a PRX5-like redoxin domain and thioredoxin domain. The gene product is annotated with thioredoxin peroxidase (TPx) activity, IgE binding, protein homodimerization activity, and metal binding. It is associated with methanol metabolism, cell redox homeostasis, hydrogen peroxide catabolic process, cellular osmotic response, and cellular response to oxidative stress. Localization evidence links the protein to the peroxisome membrane, peroxisome, mitochondria, cytoplasm, cytosol, nucleus, and extracellular space. Studies of related genes in other species connect the family to thioredoxin peroxidase/alkyl hydroperoxide reductase activity (EC 1.11.1.24).