PRR1 — Aspergillus fumigatus

Summary

AFU6G12522 (PRR1, also known as Skn7) in Aspergillus fumigatus encodes a protein with phosphorelay response regulator activity, DNA-binding transcription activator activity, and transferase activity, containing a heat shock factor DNA-binding domain and a signal transduction response regulator receiver domain. The gene is associated with responses to oxidative stress, singlet oxygen, heat, and starvation, as well as cellular thermotolerance, filamentous growth, host invasion, immune evasion, cell cycle modulation, and histidyl-aspartyl phosphorelay. It is linked to traits including oxidative stress resistance, thermotolerance, biofilm formation, spore germination, adhesion, flocculation, nutrient uptake, and cell cycle progression through G1/S and G2 phases. The protein localizes to the nucleus, cytoplasm, chromatin, and RNA polymerase II transcription regulator complex. Studies of related genes in other species connect the family to virulence and pH response.