AIM2 — Aspergillus fumigatus

Summary

AFU6G12740 (AIM2, AfAIM2) on Aspergillus fumigatus chromosome 6 encodes a dienelactone hydrolase family protein with predicted hydrolase activity (EC 3.1.1.-) and an AB_hydrolase domain. It is associated with membrane biogenesis. Phenotypic associations include decreased rate of carbon source utilization, decreased heat sensitivity, altered stress resistance (both increased and decreased oxidative stress resistance), decreased vegetative growth rate, abnormal vacuolar morphology, altered competitive fitness, and changes in chemical resistance. The gene is also linked to auxotrophy and haploinsufficiency. Studies of related genes in other species connect the family to effector function, abnormal mitochondrial genome maintenance, decreased filamentous and invasive growth, and increased metal resistance, though these roles are not established for AfAIM2 itself.