ctf1 — Aspergillus fumigatus

Summary

AFU6G11750 (symbol ctf1) on chromosome 6 of Aspergillus fumigatus encodes a putative C6 transcription factor with a Zn2Cys6 DNA-binding domain. The gene product possesses DNA-binding transcription factor activity specific to RNA polymerase II, binds DNA and zinc, and is localised to the nucleus. It is associated with positive regulation of metabolism, homologous recombination, and DNA-dependent transcription. The gene has also been linked to the proteins ads-1 (CDR4), TRF1 (PKS19), and ctf1 (MDR1). Studies of related genes in other species, such as adaR, hasF, and asaR, connect the family to unaffected pathogenicity and host interactions, including associations with barley, rice blast, fusarium ear blight, and wheat, though these findings are not established for ctf1 itself.