icsA — Aspergillus fumigatus

Summary

AFU6G12110 (symbol icsA) on Aspergillus fumigatus chromosome 6 encodes a putative salicylate synthetase with isochorismate mutase, anthranilate synthase, and oxoacid lyase activities, and belongs to the salicylate synthase and ADC synthase families. The gene is associated with tryptophan breakdown and formation, secondary metabolism, and the anthranilate synthase complex in the cytosol. It is linked to oxidative stress response. Studies of related genes in other species connect the family to EC 4.1.3.27 activity.