DO — Aspergillus fumigatus

Summary

AFU6G12400 (DO) in Aspergillus fumigatus encodes a 1,3-beta-glucan synthase, an enzyme with branched 1,3-beta-D-glucan synthase, callose synthase and alpha-1,3-glucan synthase activities (EC 2.4.1.34). The gene is associated with fungal-type cell wall polysaccharide biosynthesis, beta-glucan and chitin anabolism, ergosterol anabolism, primary and secondary cell septum biogenesis, mitotic division septum assembly, ascospore wall 1,3-beta-glucan anabolism, cell wall organization and biogenesis, chromosome condensation, immune response, conjugation with cellular fusion, and regulation of establishment or maintenance of cell polarity regulating cell shape. The product localizes to the 1,3-beta-glucan synthase complex, hyphal tip, growing cell tips, cleavage furrow, primary cell septum, spore wall, and perinuclear ER. The gene is linked to a lethal pathogen phenotype and invasive pulmonary aspergillosis. Studies of related genes in other species connect the family to sporogenesis, beta-glucan content, turgor pressure, phosphate content, acid sensitivity, and oxidative stress response.