cprA — Aspergillus fumigatus

Summary

AFU6G10990 (symbol cprA) on Aspergillus fumigatus chromosome 6 encodes a NADPH-hemoprotein reductase (EC 1.6.2.4) with NADPH dehydrogenase and electron transfer activities, binding FMN, NADP, and FAD. The protein contains flavodoxin-like and FAD-binding domains characteristic of cytochrome P450 reductases. It is associated with sterol and ergosterol biosynthesis, detoxification processes, and hypersensitivity responses. The gene product localizes to the endoplasmic reticulum membrane, mitochondrial outer membrane, plasma membrane, and cytosol. Related genes in other species link these reductases to cytochrome P450-dependent pathways, including sterol metabolism and xenobiotic detoxification.