GAS3 — Aspergillus fumigatus

Summary

AFU6G11390 (GAS3, also known as gel2) on chromosome 6 of Aspergillus fumigatus encodes a glucanosyltransferase with 1,3-beta-glucanosyltransferase activity (EC 2.4.1.-). The gene is associated with beta-1,3 glucan metabolism, ascospore wall beta-glucan anabolism, cell wall assembly and organization, hyphal growth, conidia formation, sporulation, meiosis, N-glycan processing, oxidative phosphorylation, ergosterol anabolism, and interaction with host. It is linked to aspergillosis and has been connected to phenotypes including abnormal cell wall morphology, decreased viability, increased acid pH resistance, increased sporulation efficiency, altered filamentous and pseudohyphal growth, and changes in chitin deposition, cell size, budding pattern, and telomere length. The product localizes to the cell septum edging, primary cell septum, external side of the plasma membrane, hyphal cell wall, and extracellular vesicles. Related genes in other species are linked to increased replicative lifespan.