prx1 — Aspergillus fumigatus

Summary

AFU6G11650 (symbol prx1) on chromosome 6 of Aspergillus fumigatus encodes a putative short-chain dehydrogenase/reductase (SDR family) with NAD(P)-binding domain and redox activity (EC 1.1.1.-). The gene is associated with membrane localisation and has been linked to several biological processes, including response to fungi, actin cytoskeleton organization, translation elongation, cytoskeleton organization, and terpenoid anabolism. It is also associated with oxidative stress response. Related genes in other species connect the SDR family to additional oxidoreductase activities (EC 1.1.99.-), though these functions are not yet established for the A. fumigatus gene itself.