ALP1 — Aspergillus fumigatus

Summary

AFU6G11100 (ALP1, AfALP1) in Aspergillus fumigatus chromosome 6 encodes a putative amino acid permease belonging to the APC/YAT family, with transmembrane transporter activity for L-leucine, L-arginine, and L-lysine. The gene is associated with amino acid import, including L-arginine and L-lysine uptake, as well as leucine uptake and broader amino acid membrane transport. It has been connected to biological processes such as regulation of nitrogen utilization, filamentous growth, biofilm formation, meiotic cell cycle, secretion, protein breakdown, and ergosterol anabolism. Associations with sensitization, innate immunity, phagocytosis, and immune evasion link ALP1 to host-pathogen interactions. The encoded protein localizes to the plasma membrane, cell tip, eisosome, Golgi membrane, fungal-type vacuole, and cell wall. Studies of related genes in other species link the family to reduced virulence and disseminated candidiasis.