TCSA — Aspergillus fumigatus

Summary

AFU6G10240, also known as TCSA or fos-1 in Aspergillus fumigatus on chromosome 6, encodes a histidine kinase with osmosensor, peroxide sensor, and phosphorelay sensor kinase activities, as well as histidine phosphotransfer kinase and sequence-specific DNA-binding transcription factor activity. This gene is associated with conidiophore development, regulation of conidium formation, osmolarity sensing via a two-component system, the cellular HOG response, response to singlet oxygen, regulation of the unfolded protein response, cell wall assembly, and biofilm formation on inanimate substrates. It is also linked to the downregulation of phagocytosis and calcium-independent cell-cell adhesion, activation of the p38 cascade, and cellular responses to farnesol and reactive oxygen species. The encoded protein localises to the plasma membrane, cytoplasm, nucleus, cell tip, and cell division site, and has been connected to aspergillosis.