gliT — Aspergillus fumigatus

Summary

AFU6G09740 (symbol gliT) on chromosome 6 of Aspergillus fumigatus encodes a protein belonging to the ferredoxin-NADP reductase 2 family and containing FAD/NAD-binding domains. The gene is annotated with thioredoxin reductase (NADPH) activity, oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen, monooxygenase activity, redox activity, FAD or FADH2 binding, heme binding, and iron binding. It is associated with gliotoxin anabolism, including its regulation and inhibition, as well as helvolic acid anabolism, kojic acid anabolism, nonribosomal peptide anabolism, secondary metabolism, sulfur metabolism, siderophore transport, iron transport, detoxification, secretion, autolysis, and cellular responses to mycotoxins and toxic substances. The encoded protein localises extracellularly. Related genes in other species link the family to thioredoxin reductase activity.