atrR — Aspergillus fumigatus

Summary

AFU6G10010 (atrR) on chromosome 6 of Aspergillus fumigatus encodes a putative C6 transcription factor with a Zn2Cys6 DNA-binding domain, conferring sequence-specific DNA binding and RNA polymerase II-specific transcription factor activity. The gene is associated with siderophore anabolism, reductive iron assimilation, ergosterol and sterol anabolism, sterol homeostasis, biofilm formation, hyphal growth, and hypersensitivity. It is linked to positive regulation of transcription and metabolism, and localises to both the nucleus and membrane. Studies of related genes in other species connect the AtrR-like family to reduced virulence and pulmonary aspergillosis.