PAP1 — Aspergillus fumigatus

Summary

AFU6G09930 (PAP1, also known as yap1, BZIP013, AfPAP1, or AfBZIP013) on Aspergillus fumigatus chromosome 6 encodes a bZIP transcription factor with AP-1-like and Yap1 redox domains. The product binds cis-regulatory regions and acts as an RNA polymerase II-specific DNA-binding transcription activator. This gene is associated with responses to superoxide, singlet oxygen, and lipid oxidation, as well as cellular responses to cadmium and reactive oxygen species. It is linked to ergothioneine and shamixanthone anabolism, inhibition of asperthecin and sterigmatocystin formation, and modulation of emericellin anabolism. Associations also include sexual and asexual sporulation, regulation of the unfolded protein response, and metabolic burst. The protein localizes to the nucleus, cytoplasm, and transcription regulator complexes. Studies of related genes in other species link the family to reduced virulence and unaffected pathogenicity.