gliG — Aspergillus fumigatus

Summary

AFU6G09690 (symbol gliG) on Aspergillus fumigatus chromosome 6 encodes a protein with glutathione transferase, glutathione peroxidase, and O-methyltransferase activities, and is annotated with phosphoprotein, pyridoxal phosphate, and protein dimerization binding, as well as transcription corepressor activity. The gene is associated with gliotoxin and mycotoxin anabolism, secondary metabolism, detoxification, nitrate assimilation, regulation of nitrogen utilization, protein urmylation, methylation, and negative regulation of transcription by RNA polymerase II. Its product localizes to the cytoplasm. Studies of related genes in other species link the family to additional transferase and methyltransferase activities, though these functions are not established for gliG itself.