gliM — Aspergillus fumigatus

Summary

AFU6G09680 (symbol gliM) in Aspergillus fumigatus chromosome 6 encodes a protein with O-methyltransferase and glutathione transferase activities, belonging to the SAM-dependent methyltransferase superfamily and featuring a COMT dimerisation domain. This gene is associated with gliotoxin and mycotoxin anabolism, secondary metabolite biosynthesis, methylation, and suppression by symbiont of host immune response. It is also linked to L-7-dimethylallyltryptophan and imino-3-phenyl-propionic acid. Studies of related genes in other species, including verM, etpM, aclU, sirM, aclM, and pgmB, connect the family to additional transferase activities (EC 2.5.1.18 and EC 2.6.1.-), though these associations are not yet established for gliM itself.