gliP — Aspergillus fumigatus

Summary

AFU6G09660 (symbol gliP) on chromosome 6 of Aspergillus fumigatus encodes a multimodular enzyme with adenylation, condensation, and phosphopantetheine-binding domains, classified as a ligase (EC 6.3.2.-) and associated with isomerase activity. The gene is linked to nonribosomal peptide biosynthesis, specifically gliotoxin and mycotoxin anabolism, as well as secondary metabolism, pigmentation, morphogenesis, and regulation of gene expression. It is associated with processes including chemokine anabolism, mast cell degranulation, angiogenesis, tube formation, phagocytosis, and the metabolic burst. The encoded protein localises to the cytoplasm. Studies of related genes in other species, such as verP, etpP, and criC, link the family to additional nonribosomal peptide synthetase functions.