gliJ — Aspergillus fumigatus

Summary

AFU6G09650 (symbol gliJ) on chromosome 6 of Aspergillus fumigatus encodes a metallodipeptidase (EC 3.4.13.19) belonging to the Pept_M19 family, with metal-binding and dipeptidase activity. The gene is associated with regulation of gliotoxin anabolism, kojic acid anabolism, suppression by symbiont of host immune response, gliotoxin anabolism, sulfur metabolism, mycotoxin anabolism, detoxification, secretion, and proteolysis. The encoded protein localises to the membrane. Studies of related genes in other species, including verJ, tcpJ, sirJ, and aclJ, connect the dipeptidase family to secondary metabolite biosynthesis pathways, though these associations are not yet established for gliJ itself.