AC1 — Aspergillus fumigatus

Summary

AFU6G08520 (AC1, acyA) encodes a protein with adenylyl cyclase activity and MAP kinase serine/threonine phosphatase activity, belonging to the adenylate cyclase G-alpha-binding and A/G cyclase domain families. In Aspergillus fumigatus, the gene is associated with the cAMP/PKA signaling cassette, cAMP anabolism, glucose-sensing PKA pathway, cellular osmotic response, and negative regulation of transcription by RNA polymerase II. The protein localizes to the plasma membrane, cytoplasm, cytosol, and nucleus. Phenotypic associations include abnormal spore germination, filamentous growth, and pseudohyphal growth; increased adhesion, anaerobic growth, and necrotic cell death; decreased lifespan and entry into G0; and absent desiccation and hyperosmotic stress resistance. Studies of related genes in other species link the family to loss of pathogenicity and cell cycle arrest at START, as well as calcium sensitivity.