ATG5 — Aspergillus fumigatus

Summary

AFU6G07040 (ATG5) in Aspergillus fumigatus encodes a protein with APG8 ligase activity, containing ATG5_HBR, Atg5_HR, ATG5_UblA, and ATG5_UblB domains. The gene is associated with autophagy, mitophagy, aggrephagy, and the cellular response to nitrogen starvation, and its product localizes to the Atg12-Atg5-Atg16 complex, phagophore, and pre-autophagosomal structure membrane. Phenotypic associations include abnormal autophagy, absent mitophagy and filamentous growth, decreased colony size, increased mitochondrial rho- mutation frequency, and altered nucleophagy, ribophagy, and pexophagy. The gene is also linked to protein transport, phagocytosis, and protein positioning. Related genes in other species connect it to oxidative stress response.