AUS1 — Aspergillus fumigatus

Summary

AfAUS1 (AFU6G08020) encodes a putative ABC transporter of the PDR/CDR subfamily, possessing ATP-coupled transmembrane transporter activity and ATP hydrolase activity. In Aspergillus fumigatus, the gene is associated with steroidogenesis, ergosterol anabolism, carbohydrate metabolism, mating, cell growth, and hypersensitivity. It is linked to xenobiotic detoxification via transmembrane export across the plasma membrane and response to antibiotics. The product localises to the plasma membrane. Phenotypic associations include abnormal small molecule transport, increased sporulation rate, decreased cell death rate, delayed exit from stationary phase, and increased fermentative growth, alongside numerous other cellular and metabolic abnormalities.