GPI7 — Aspergillus fumigatus

Summary

AFU6G05260, designated AfGPI7, encodes a protein belonging to the PIG-G_N and PIGG/GPI7_C domain families, with predicted phosphotransferase and alkaline phosphatase core superfamily activity. The gene is associated with GPI anchor metabolism and anabolism, autophagy, filamentous growth in response to starvation and biotic stimulus, morphogenesis, and the immune response. Its product localises to the ER membrane and plasmalemma. AfGPI7 is linked to numerous phenotypes including abnormal flocculation, decreased protein modification, absent hyperosmotic stress resistance, increased X-ray resistance, increased G2/M phase cell cycle progression, abnormal entry into stationary phase, absent protein secretion, and increased survival rate in stationary phase. The gene is also associated with invasive pulmonary aspergillosis and has been studied in mouse models.