ABZ1 — Aspergillus fumigatus

Summary

AFU6G04820 (ABZ1, pabA) in Aspergillus fumigatus encodes a para-aminobenzoate synthase. The gene is associated with aminodeoxychorismate synthase activity, anthranilate synthase activity, phosphoribosylanthranilate isomerase activity, indole-3-glycerol-phosphate synthase activity, and lyase activity. It is linked to folate biosynthesis, tetrahydrofolate anabolism, PABA biosynthesis, tryptophan formation, siderophore anabolism, lysine anabolism, and amino acid anabolism. It is also associated with sporulation and ribosome biogenesis. Phenotypic associations include delayed RNA accumulation, normal exponential growth rate, delayed G1/S phase transition, decreased nuclear export, abnormal RNA localization, decreased autophagy, absent protein modification, decreased silencing, decreased nucleolus size, decreased telomere length, increased protein modification, decreased exponential growth rate, decreased RNA accumulation, increased chemical compound excretion, decreased protein modification, increased invasive growth, decreased starvation resistance, decreased protein accumulation, inviability, abnormal protein distribution, increased heat sensitivity, increased chemical compound accumulation, haploinsufficiency, decreased competitive fitness, and increased or decreased chemical resistance. The gene product localizes to the cytoplasm, cytosol, nucleus, and the anthranilate synthase complex.