TCU-3 — Aspergillus fumigatus

Summary

AFU6G02810 (symbol TCU-3, also known as ctrA2) on Aspergillus fumigatus chromosome 6 encodes a Cop_transporter family protein with copper ion transmembrane transporter activity. The gene is associated with response to copper, copper ion membrane transport, and homeostasis, as well as conidiophore development. Its product localises to the plasmalemma. TCU-3 has also been linked to zinc concentration. Studies of related genes in other species connect the family to pulmonary aspergillosis and mouse models, though pathogenicity was unaffected in some relatives.