fluG — Aspergillus fumigatus

Summary

AFU6G03530 (fluG) on chromosome 6 of Aspergillus fumigatus encodes a protein with glutamine synthetase and hydrolase activities, ATP binding, and a glutamine synthetase catalytic domain. The gene is associated with glutamine metabolism, asexual reproduction, sporocarp development, conidium formation, hyphal growth, autolysis, and the regulation of sterigmatocystin and aflatoxin biosynthetic processes, including positive regulation of sterigmatocystin production and conidium formation. It is also linked to secondary metabolism, sterol metabolism, and amine metabolism. The encoded protein localizes to the cytoplasm. Studies of related genes in other species connect the family to oxidative stress response, though this has not been established in A. fumigatus.