fmpE — Aspergillus fumigatus

Summary

AFU6G03480 (symbol fmpE) in Aspergillus fumigatus chromosome 6 encodes a multidomain protein with thioester reductase-like, aminotransferase, acyl-adenylating, and carrier protein domains, and exhibits L-aminoadipate-semialdehyde dehydrogenase, ligase, transferase, isomerase, and redox activities. The gene is associated with amino acid activation for nonribosomal peptide biosynthesis, small molecule and alkaloid metabolism, sporulation, and secondary metabolite biosynthesis. Its product localizes to the cytoplasm. FmpE is also linked to oxidative stress response. Studies of related genes in other species connect the family to reduced virulence and fusarium head blight, though these associations are not established for A. fumigatus itself.