mtfA — Aspergillus fumigatus

Summary

AFU6G02690 (mtfA, also known as C2H076) on chromosome 6 of Aspergillus fumigatus encodes a C2H2 zinc finger domain protein, putative, with DNA-binding transcription repressor activity, RNA polymerase II-specific. The product is localised to the nucleus and is associated with regulation of asexual sporulation, gliotoxin anabolism, cellular zinc ion homeostasis, secondary metabolism, morphogenesis, negative regulation of transcription by RNA polymerase II, and regulation of gene expression. The gene is linked to pulmonary aspergillosis and has been studied in the Galleria mellonella infection model. Studies of related genes in other species, such as C2H2 conidiation transcription factor FlbC, connect the family to developmental regulation, though these associations are not yet established for this specific gene.